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New Research: Sialic Acids May Contribute to Inflammation & Disease

New Research: Sialic Acids May Contribute to Inflammation & Disease

Dr. Roger Seheult of MedCram explains new research on Neu5Gc, a sialic acid molecule found in meat and dairy, and how it may contribute to severe COVID-19 symptoms, inflammation, and certain chronic diseases and cancers.

Roger Seheult, MD is the co-founder and lead professor at MedCram https://www.medcram.com
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.

Interviewer: Kyle Allred, Physician Assistant, Producer, and Co-Founder of MedCram.com

This video was recorded on May 13, 2021

TOPICS IN THIS VIDEO INCLUDE:

00:00 Introduction to sialic acids and why they’re important
00:39 What are sialic acids?
01:53 Introduction to Neu5Ac (in humans) & Neu5Gc (in other mammals)
03:41 Why are Neu5Ac and Neu5Gc important?
05:41 Human antibodies against Neu5Gc-glycans, chronic inflammation, & xenosialitis
07:21 French NutriNet-Sante study and “Gcemic Index” of foods
08:40 Does just red meat contain Neu5Gc? What about poultry, eggs, & fish?
09:14 Neu5Gc intake differences in men & women
10:26 Association between BMI, plant-based diets, & sialic acids
13:02 Cycle of obesity & inflammation
13:30 Biologic therapy & coronary inflammation
14:51 Dr. Esselstyn’s work on diet & coronary artery disease
16:01 Risks of meat consumption – processed versus unprocessed
20:00 Health benefits of red meat consumption
22:01 Summary of diets & associated outcomes, looking ahead to COVIDENCE UK Study

LINKS / REFERENCES:

Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells (Journal of Biological Chemistry) | https://pubmed.ncbi.nlm.nih.gov/15557321/

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc (Frontiers in Immunology) | https://www.frontiersin.org/articles/10.3389/fimmu.2019.00807/full

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study (BMC) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510162/

Adventist Health Study-2 (Loma Linda University Health) | https://adventisthealthstudy.org/studies/AHS-2

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index (JAMA) | https://pubmed.ncbi.nlm.nih.gov/31365032/

A plant-based diet and coronary artery disease: a mandate for effective therapy (Journal of Geriatric Cardiology) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466936/

Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study (BMC) | https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-01922-9#citeas

The COVIDENCE UK Research Study has been developed in response to the outbreak of coronavirus disease (Queen Mary University of London) | https://www.qmul.ac.uk/covidence/about-the-covidence-uk-study/

All coronavirus updates are at MedCram.com (including more discussion on: does red meat cause cancer, cardiovascular disease, sialic acid, dairy and red meat cancer, COVID 19 Vaccines, and more).

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#COVID19 #SialicAcid #Neu5Gc