RT’s Three Key Takeaways:
- Zepbound Authorised for Weight problems-Associated OSA: The FDA permitted Zepbound for treating moderate-to-severe obstructive sleep apnea in adults with weight problems, providing a brand new remedy choice.
- Limitations of Zepbound: The AASM harassed that Zepbound is efficient just for obesity-related OSA and will not treatment the situation. Combining it with different therapies could also be needed for some sufferers.
- Potential Dangers and Significance of Weight Upkeep: The AASM reminded sufferers of the potential well being dangers related to Zepbound and the necessity to keep weight reduction to proceed experiencing advantages for sleep apnea.
The US Meals and Drug Administration (FDA) has permitted Zepbound (tirzepatide) as a remedy for adults with moderate-to-severe obstructive sleep apnea (OSA) and weight problems.
This approval, introduced by Eli Lilly on Dec 20, 2024, marks a step ahead within the administration of OSA, in response to a press release issued by the American Academy of Sleep Medication (AASM). “The FDA approval of Zepbound for reasonable to extreme obstructive sleep apnea in adults with weight problems is a constructive improvement for sufferers and clinicians, who now have one other remedy choice for this sleep problem,” the assertion reads.
Nevertheless, the AASM additionally highlights that Zepbound is just efficient in circumstances of sleep apnea related to weight problems. Whereas extra physique weight is a significant factor in OSA, different components, similar to jaw and higher airway construction, may contribute to the situation. “Though extra physique weight is the key predisposing issue for sleep apnea, many circumstances of sleep apnea are associated to different components such because the construction of the jaw and higher airway,” the assertion notes.
The AASM emphasizes that whereas Zepbound can cut back the severity of sleep apnea, it could not treatment the situation. “Due to this fact, for some sufferers who’ve sleep apnea, combining one other remedy with Zepbound could also be perfect,” the assertion reads. “Moreover, weight reduction from Zepbound should be maintained over time to proceed experiencing a profit for sleep apnea.”
The group additionally reminds sufferers that Zepbound carries potential well being dangers and negative effects, that are outlined on the FDA-approved drug label.
For sufferers searching for steerage, the AASM notes that sleep physicians and consultants at AASM-accredited sleep facilities may also help sufferers who’ve sleep apnea decide if Zepbound is suitable for them. The AASM offers a listing to find sleep facilities and professionals.
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