Home Food Allergies Effectiveness of Sublingual Epinephrine Not Affected by Oral Temperature or pH

Effectiveness of Sublingual Epinephrine Not Affected by Oral Temperature or pH

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Aquestive Therapeutics introduced constructive topline knowledge from their latest section 2 research of Anaphylm™, a tiny movie positioned underneath the tongue to deal with anaphylaxis.

The one-dose, five-period, randomized crossover research was designed to match the pharmacokinetics (PK) and pharmacodynamics (PD) of Anaphylm simply after consuming regular water (sizzling, chilly, and room temperature), lemon water, and baking soda water.

PK describes the focus of a drug in physique fluids over time ensuing from administration of a sure drug dose, PD is the noticed impact ensuing from a sure drug focus.

Earlier research have proven that Anaphylm’s PK and PD are akin to these of conventional epinephrine auto-injectors.

Topline PK knowledge from the research confirmed no statistically important distinction in PK outcomes primarily based on adjustments in temperature and pH. Essentially the most consumed drinks, reminiscent of soda, milk, espresso, and juice, have acidity between lemon water and regular water. Whereas not statistically important, alkaline substances like baking soda confirmed a considerably increased absorption degree than room-temperature water.

Stated Daniel Barber, President and CEO of Aquestive:

The constructive topline knowledge from this research reinforce that Anaphylm has the potential to be seamlessly built-in into sufferers’ each day lives. A latest independently carried out survey reported that 100% of sufferers and caregivers who participated within the survey indicated they might not return house to retrieve an autoinjector, if forgotten. Breaking this regarding cycle of not carrying epinephrine, the one first-line therapy for anaphylaxis, requires a product that’s straightforward to recollect, straightforward to hold, and simple to make use of even after consumption of a beverage or meals. We imagine Anaphylm possesses these important attributes and has the potential to rework the lives of individuals in danger for extreme and life-threatening allergic reactions, if accredited by the FDA.

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