Home Insect Allergies How Physique Weight Impacts Immune Response to COVID-19

How Physique Weight Impacts Immune Response to COVID-19


Being obese can impair the physique’s antibody response to SARS-CoV-2 an infection, however to not the safety provided by vaccination, in accordance with analysis revealed in Scientific & Translational Immunology.

The analysis, carried out by scientists at College of Queenslan construct on current analysis on how COVID-19 impacts people who find themselves obese.

“We’ve beforehand proven that being obese – not simply being overweight – will increase the severity of SARS-CoV-2,” stated analysis lead Marcus Tong, a PhD candidate at UQ’s College of Chemistry and Molecular Biosciences. “However this work reveals that being obese creates an impaired antibody response to SARS-CoV-2 an infection however to not vaccination.”

The analysis group collected blood samples from individuals who had recovered from COVID-19 and never been reinfected throughout the research interval, roughly 3 months and 13 months post-infection.

“At 3 months post-infection, an elevated BMI was related to lowered antibody ranges,” Mr Tong stated. “And at 13 months post-infection, an elevated BMI was related to each lowered antibody exercise and a lowered share of the related B cells, a kind of cell that helps construct these COVID-fighting antibodies.”

In distinction, an elevated BMI had no impact on the antibody response to COVID-19 vaccination at roughly 6 months after the second vaccine was administered.

Affiliate Professor Kirsty Brief stated the outcomes ought to assist form well being coverage transferring ahead.

“If an infection is related to an elevated threat of extreme illness and an impaired immune response for the obese, this group has a probably elevated threat of reinfection,” Dr Brief stated.

“It makes it extra vital than ever for this group to make sure they’re vaccinated.”

Dr Brief stated from a public well being perspective, this knowledge attracts into query insurance policies round boosters and lockdowns.

“We’d recommend that extra personalised suggestions are wanted for obese individuals, each for ongoing COVID-19 administration and future pandemics,” she stated.

“Lastly, the info gives an added impetus to enhance SARS-CoV-2 vaccination in low-income nations, the place there’s a excessive share of people who find themselves obese and are depending on infection-induced immunity.”

The analysis is revealed in Scientific & Translational Immunology.

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