Home Food Allergies Nasal Emergency Epinephrine Different Reveals Optimistic Topline Knowledge in Scientific Research

Nasal Emergency Epinephrine Different Reveals Optimistic Topline Knowledge in Scientific Research

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  • OX640 is a nasal rescue medicine with powder-based epinephrine for the remedy of allergic reactions (incl. anaphylaxis) and relies on the proprietary AmorphOX® expertise
  • The medical research, OX640-002, evaluated each pharmacokinetic and pharmacodynamic results of OX640 in topics with and with out allergic rhinitis
  • OX640 remedies achieved clinically related plasma ranges of epinephrine extra quickly than the intramuscular reference product
  • Absorption from OX640 beneath allergic rhinitis situations was considerably quicker than beneath regular situations, supporting fast onset of impact additionally in sufferers with airway signs.

Uppsala, Sweden – January 10, 2025 – Orexo AB (publ.), (STO:ORX) (OTCQX:ORXOY), right this moment publicizes optimistic topline outcomes from the medical research OX640-002. The research evaluated the efficiency in topics with and with out allergic rhinitis when handled with Orexo´s nasal rescue medicine together with powder-based epinephrine, OX640.

The research was a cross-over research in 30 topics assessing absorption and pharmacodynamic results of epinephrine from two doses of OX640, with one of many doses additionally administered throughout ongoing allergic rhinitis signs. Publicity was in comparison with a business intramuscular injection.

Topline information evaluation demonstrates that OX640 remedies achieved imply epinephrine plasma ranges related to medical efficacy extra quickly than the intramuscular injection, with dose-dependent publicity ranges. Absorption beneath allergic rhinitis situations was considerably quicker than beneath regular situations, supporting fast onset of impact additionally in sufferers with important airway signs. OX640 formulations usually produced extra pronounced will increase in blood strain and coronary heart charge than the intramuscular injection, that are key results for remedy of anaphylaxis.

Systemic security was in step with the recognized pharmacology of epinephrine and native results have been transient and tolerated. There have been no extreme or severe hostile occasions.

Robert Rönn, SVP and Head of R&D, stated: “We’re happy with the end result of the research which additional assist the utility of our OX640 epinephrine nasal powder for remedy of anaphylaxis, even in case of allergic rhinitis signs. Importantly, the research outcomes enable us to resolve on the ultimate business formulation and dose, which is vital to advance the venture in direction of regulatory approval. The info additional reinforces our view that OX640 has the potential to be a singular and differentiated needle-free epinephrine product.”

For additional info please contact:

Nikolaj Sørensen, President and CEO
Lena Wange, IR & Communications Director
Robert Rönn, SVP and Head of R&D
Tel: +46 (0)18 780 88 00
E-mail: ir@orexo.com

About Orexo
Orexo is a Swedish pharmaceutical firm with 30 years of expertise creating improved prescription drugs based mostly on proprietary formulation applied sciences that meet massive medical wants. On the US market, Orexo supplies revolutionary remedy options for sufferers affected by opioid use dysfunction and adjoining ailments. Merchandise concentrating on different therapeutic areas are developed and commercialized worldwide with main companions. Whole web gross sales in 2023 amounted to SEK 639 million, and the variety of workers to 116. Orexo is listed on Nasdaq Stockholm’s essential record and is offered as an ADR on OTCQX (ORXOY) within the US.

For extra info on Orexo, go to www.orexo.com. Observe Orexo on X, LinkedIn, and YouTube.

About AmorphOX® 
Orexo’s proprietary drug supply platform, AmorphOX, is a powder made up of particles that are constructed utilizing a singular mixture of a drug, service supplies and, optionally, different components. The particles are offered as an amorphous composite of the assorted components offering for glorious chemical and bodily stability, in addition to fast dissolution. The expertise works for a broad scope of lively components and has been validated in a number of human medical research displaying fast and intensive drug publicity. 

About research OX640-002
The research was a 4-period cross-over research in 30 in any other case wholesome topics with seasonal allergic rhinitis. The research was performed off allergy season with no ongoing allergy signs in topics. Epinephrine plasma ranges, blood strain and coronary heart charge have been collected after administration of two totally different doses of OX640 and 0.3 mg intramuscular epinephrine. In a single remedy interval, one of many OX640 doses was administered following nasal administration of allergens, producing acute allergic rhinitis signs within the topics.

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