RT’s Three Key Takeaways:
- Glucagon-like peptide-1 receptor agonists (GLP-1RAs), together with drugs like Ozempic and Wegovy used for diabetes and weight problems, are linked to an elevated danger of aspiration pneumonia following endoscopy, as per analysis from Cedars-Sinai.
- The research, printed in Gastroenterology, analyzed information from almost 1 million de-identified US sufferers who underwent higher or decrease endoscopy procedures between January 2018 and December 2020, discovering that sufferers prescribed GLP-1RA drugs had a 33% increased probability of experiencing aspiration pneumonia in comparison with those that didn’t take these drugs.
- Sufferers scheduled for procedures ought to talk with their healthcare workforce prematurely and contemplate halting GLP-1RA drugs to keep away from potential problems, researchers recommend.
New analysis from Cedars-Sinai suggests people who find themselves scheduled for sure medical procedures ought to cease taking fashionable weight reduction medicine within the days or even weeks previous to keep away from problems.
Investigators discovered glucagon-like peptide-1 receptor agonists (GLP-1RAs)—drugs like Ozempic and Wegovy which are used to deal with diabetes and weight problems—are related to an elevated danger of aspiration pneumonia following endoscopy.
The big, population-based research is printed in Gastroenterology.
Weight problems Medication and Endoscopy Problems
Aspiration pneumonia is attributable to inhaling overseas supplies—together with meals within the abdomen, or secretions from the mouth and nostril—into the lungs. A technique the brand new weight problems drugs work is by slowing digestion, so folks really feel full longer, inflicting them to eat much less. This additionally implies that meals sits within the abdomen longer.
In consequence, the abdomen could not empty fully through the regular length of fasting that’s really helpful forward of a surgical process to lower the danger of aspiration, explains the research’s corresponding creator, Ali Rezaie, MD, medical director of the GI Motility Program and director of bioinformatics on the MAST Program at Cedars-Sinai, in a launch.
“Aspiration throughout or after endoscopy might be devastating,” Rezaie says in a launch. “If vital, it may result in respiratory failure, ICU admission, and even loss of life. Even gentle instances could require shut monitoring, respiratory help, and drugs together with antibiotics. It’s important we take all potential precautions to forestall aspiration from occurring.”
A Have a look at the Research
The research analyzed information from almost 1 million de-identified US sufferers who underwent higher or decrease endoscopy procedures between January 2018 and December 2020. Sufferers who have been prescribed GLP-1RA drugs had a 33% increased probability of experiencing aspiration pneumonia than those that didn’t take these drugs earlier than the process.
This comparability additionally thought-about different variables that would affect the end result to make sure a good comparability between the 2 teams.
“Once we apply this danger to the greater than 20 million endoscopies which are carried out within the US annually, there may very well be a lot of instances the place aspiration could possibly be averted if the affected person safely stops their GLP-1RA treatment prematurely,” Rezaie says in a launch.
“The outcomes of this research may change medical follow,” says Yee Hui Yeo, MD, first creator of the research and a medical fellow within the Karsh Division of Gastroenterology and Hepatology at Cedars-Sinai, in a launch. “Sufferers taking these drugs who’re scheduled to bear a process ought to talk with their healthcare workforce properly prematurely to keep away from pointless and undesirable problems.”
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