New analysis suggests irritation and immune system modifications could make it tougher for the physique to heal
ORLANDO (Nov. 6, 2025) – Two new research being offered on the 2025 Annual Scientific Assembly of the American Faculty of Allergy, Bronchial asthma and Immunology (ACAAI) present that individuals with allergic situations — together with eczema, bronchial asthma, and hay fever — could face extra issues after sure sorts of surgical procedure. The analysis means that the irritation and immune system modifications that include these situations could make it tougher for the physique to heal and will enhance the danger of an infection after surgical procedure.
In a single massive research, researchers checked out greater than 20,000 girls who had breast reconstruction after most cancers surgical procedure. These with eczema, dermatitis, or different allergic pores and skin situations have been extra more likely to have issues with their breast implants — together with infections, scar tissue buildup (referred to as capsular contracture), and implant rupture — than girls with out these situations.
Over the three years following surgical procedure, sufferers with atopic (allergic) pores and skin illness have been additionally extra more likely to want implant removing or further surgical procedures to repair issues.
“Folks with eczema or related pores and skin situations have already got extra delicate pores and skin and a better degree of irritation,” mentioned Philong Nguyen, BS, lead writer of the research. “That appears to make surgical therapeutic harder and will increase the possibility of an infection.”
In a second research by a number of the similar investigators, the researchers checked out greater than 38,000 adults who had bone graft surgical procedure, typically used to restore or rebuild bone. These with allergic situations akin to eczema, bronchial asthma, or hay fever had increased charges of an infection, bone irritation (referred to as osteomyelitis), and the necessity for extra surgical procedure to take away or substitute implants.
“Even two years after their preliminary surgical procedure, individuals with atopic situations have been nonetheless extra more likely to have issues like an infection or implant loosening,” mentioned Joshua Wang, MS, lead writer of the research.
“These outcomes recommend that allergic situations can have an effect on the physique’s capability to heal after surgical procedure — not simply within the pores and skin, however within the bones as effectively.”
Authors of each research agree that consciousness of this danger could inform preoperative counseling and immediate extra vigilant postoperative monitoring on this affected person inhabitants.
Summary Title: Affiliation Between Atopic Pores and skin Illness and Implant-Associated Issues in Breast Reconstruction (Full summary beneath)
Presenter: Philong Nguyen, BS (longnguy@utmb.edu) 972-330-7492
Summary Title: Atopic Illness is Related to Elevated Issues Following Bone Grafting: A Multicenter Retrospective Cohort Research (Full summary beneath)
Presenter: Joshua Wang, MS (joswang@utmb.edu) 858-603-1795
For extra details about analysis and therapy of allergic situations, or to seek out an allergist in your space, go to AllergyandAsthmaRelief.org. The ACAAI Annual Scientific Assembly is Nov. 6-10. For extra information and analysis from the ACAAI Scientific Assembly, go to our newsroom and comply with the dialog on X/Twitter #ACAAI25.
About ACAAI
The American Faculty of Allergy, Bronchial asthma & Immunology (ACAAI) is knowledgeable medical group of greater than 6,000 allergists-immunologists and allied well being professionals, headquartered in Arlington Heights, In poor health. Based in 1942, the Faculty fosters a tradition of collaboration and congeniality through which its members work collectively and with others towards the widespread objectives of affected person care, schooling, advocacy, and analysis. ACAAI allergists are board-certified physicians educated to diagnose allergy symptoms and bronchial asthma, administer immunotherapy, and supply sufferers with the most effective therapy outcomes. For extra info and to seek out aid, go to AllergyandAsthmaRelief.org. Be a part of us on Fb, Pinterest, Instagram, Threads and X.
R290
ASSOCIATION BETWEEN ATOPIC SKIN DISEASE AND IMPLANT-RELATED COMPLICATIONS IN BREAST RECONSTRUCTION
P. Nguyen*1, J. Wang1, A. Pham1, H. Chan1, T. Nguyen1, W. Lee1, Y. Tanas2, 1. Galveston, TX; 2. Houston, TX.
Introduction: Capsular contracture is a standard complication of implant-based breast reconstruction. Whereas recognized danger components embrace an infection, radiation, and affected person components, the affect of preexisting atopic pores and skin situations stays unclear. Given their barrier defects and immune dysregulation, atopic sufferers could also be extra susceptible to irritation, an infection, and fibrosis. This research investigates the affiliation between atopic pores and skin situations and implant-related issues.
Strategies: We recognized feminine breast most cancers sufferers aged ≥18 who underwent implant-based reconstruction (2002–2022) utilizing ICD-10 and CPT codes. Sufferers have been stratified by prior diagnoses of eczema, dermatitis, or different allergic pores and skin situations. Propensity rating matching balanced demographics, comorbidities, autoimmune illnesses, and therapy exposures (radiation, chemotherapy, hormone remedy, steroids). Outcomes included capsular contracture, implant issues, and revision surgical procedures. Danger ratios (RRs) have been calculated at 1, 2, and three years post-op, with significance set at p < 0.05.
Outcomes: After matching every cohort had 10,205 sufferers. Sufferers with atopic situations had considerably increased dangers of implant issues (RR=1.2,p<0.0001), capsular contracture at 2&3 years (RR=1.2,p≤0.0005), and revision surgical procedures in any respect time factors (RR=1.1,p<0.001) than these with out atopic or allergic pores and skin situations. Implant removing danger was elevated at 1,2,&3 years (RR=1.2,p≤0.004), rupture danger elevated at 2&3 years (RR=1.4,p≤0.0457), and implant an infection charges have been increased in any respect time factors (RR=1.2,p≤0.0009).
Conclusion: Atopic pores and skin situations are related to elevated danger of implant issues and revision surgical procedures. This multi-timepoint evaluation underscores the worth of complete danger evaluation to tell surgical planning and affected person care.
R291
ATOPIC DISEASE IS ASSOCIATED WITH INCREASED COMPLICATIONS FOLLOWING BONE GRAFTING: A MULTICENTER RETROSPECTIVE COHORT STUDY
J. Wang*1, P. Nguyen1, A. Pham1, H. Chan1, T. Nguyen1, Y. Tanas2, 1. Galveston, TX; 2. Houston, TX.
Introduction: Atopic illnesses, together with bronchial asthma, atopic dermatitis, and allergic rhinitis, are marked by continual immune dysregulation, which can impair wound therapeutic and enhance susceptibility to postoperative issues. Whereas their results on mushy tissue therapeutic are effectively documented, their affect on bone graft outcomes stays unclear. This research aimed to guage atopic illness’s affect on bone grafting complication.
Strategies: A retrospective cohort research was performed utilizing the TriNetX analysis community. Grownup sufferers with documented bone grafting procedures and prior atopic illness have been in comparison with a matched cohort with out atopic illness utilizing 1:1 propensity rating matching based mostly on demographics and comorbidities. Postoperative outcomes have been assessed at 90 days and a pair of years. Hazard ratios (HR) with 95% confidence intervals (CI) have been calculated for every final result of curiosity. Significance is ready at p<0.05.
Outcomes: After propensity rating matching the atopic and no atopic cohorts had 19,334 sufferers every. At 90 days, sufferers with atopic illness demonstrated increased dangers of an infection or wound issues(HR=1.19,95percentCI=1.08–1.32), osteomyelitis(HR=1.29,95percentCI=1.12–1.48), and {hardware} removing (HR=1.22,95percentCI=1.05–1.41). At 2 years, the atopic cohort remained at elevated danger for an infection or wound issues (HR=1.20,95percentCI=1.11–1.31), osteomyelitis (HR=1.20,95percentCI=1.08–1.33), {hardware} removing (HR=1.21,95percentCI=1.11–1.33), mechanical loosening(HR=1.35,95percentCI=1.17–1.56) and revision surgical procedure (HR=1.16,95percentCI=1.09–1.25). No variations noticed in graft failure, pathological fractures, surgical intervention/debridement, or opioid abuse.
Conclusion: Sufferers with atopic illness present process bone grafting procedures expertise increased charges of infection-related issues, {hardware} removing, and revision surgical procedure, notably at longer-term follow-up. Consciousness of this danger could inform preoperative counseling and immediate extra vigilant postoperative monitoring on this affected person inhabitants.
