Needle-free, nasal supply of epinephrine has been proven to be an efficient and secure remedy for anaphylaxis.
MILWAUKEE – Nasal powder formulations of epinephrine demonstrated superior stability and comparable plasma publicity to EpiPens based on new analysis being introduced on the 2024 American Academy of Allergy, Bronchial asthma & Immunology Annual Assembly.
“After greater than 100 years of medical use, a needle-free possibility for epinephrine lastly appears to be inside attain, because of new supply applied sciences mixed with efforts from regulatory companies to discover a scientifically sound growth path. The nasal amorphous powder expertise now we have developed gives each efficient absorption and glorious stability that will profit sufferers, making certain that the drug isn’t degraded when carried and continues to be efficient when wanted” says lead creator, Martin Jönsson, MSc Pharm.
In a 5-period, cross-over research with 40 wholesome volunteers, researchers evaluated the bioavailability and hemodynamic response of 4 1 mg powder formulations in comparison with a 0.3 mg EpiPen. Within the research, proprietary amorphous powder formulations had been developed utilizing spray-drying, and the steadiness of these formulations was evaluated underneath accelerated situations and in comparison with the EpiPen.
The preservative-free powder formulations had been secure underneath accelerated situations, with lower than 1% complete degradation over 12 months in comparison with 32% degradation for the EpiPen. Powder formulations of epinephrine had been quickly absorbed with comparable plasma ranges to EpiPens reached inside about 5-10 minutes. The research discovered that peak and early baseline adjusted publicity ranges had been additionally akin to the EpiPen, starting from an estimated 83% to 120% of EpiPen ranges relying on the system, and complete publicity was about 30% to 60% larger for the nasal powders. Onset of hemodynamic results, each blood stress and coronary heart fee, had been akin to these related to EpiPen utilization, with considerably larger improve in blood stress. The findings recommend nasal powder formulations of epinephrine demonstrated superior stability and comparable plasma publicity to EpiPens, making them an efficient remedy possibility for sufferers.
As remedy choices for anaphylaxis are at the moment restricted to parenteral autoinjectors, with needle-based administration that will deter well timed use, nasal epinephrine powders can tackle shortcomings of present autoinjectors, and make them a extra accessible possibility for sufferers sooner or later.
Go to aaaai.org to study extra about anaphylaxis. Analysis introduced on the 2024 AAAAI Annual Assembly, February 23-26 in Washington, DC, is printed in a web-based complement to The Journal of Allergy and Scientific Immunology.
The American Academy of Allergy, Bronchial asthma & Immunology (AAAAI) is the main membership group of greater than 7,100 allergists, bronchial asthma specialists, medical immunologists, allied well being professionals and different professionals with a particular curiosity within the analysis and remedy of allergic and immunologic ailments. Established in 1943, the AAAAI has greater than 7,100 members in the USA, Canada and 72 different international locations and is the go-to useful resource for sufferers residing with allergic reactions, bronchial asthma and immune deficiency problems.
