Final week, our science group’s analysis was printed in one of the crucial prestigious scientific journals: Scientific Reviews, printed by Nature Publishing Group.
The paper builds on our first publication from Might in Meals Chemistry, which laid the inspiration for our detection platform. This more moderen paper introduces a number of the extra novel features of our sensing methodology, and expands on our meals testing capabilities.
Peer-reviewed publications could be dense, so we thought we’d break down the importance of our paper in layman’s phrases.
Meals are complicated. They usually comprise giant numbers of various substances, which differ in acidity, oil content material, and texture. These variables require that we carry out intensive meals testing to make sure the Amulet can precisely decide the presence or absence of allergenic substances even in essentially the most ingredient-diverse and sophisticated dishes. As a part of our testing, we chosen a variety of meals to maximise the vary of complexity, substances, and textures.
We should additionally present that our sensors work persistently and at clinically related ranges—the bottom quantity of allergen that triggers an allergic response in essentially the most delicate food-allergic people.
Traditionally, our core expertise has been recognized for its extremely delicate and selective properties, which interprets to low charges of each false positives (e.g., detecting allergens in allergen-free meals), and false negatives (e.g., failing to detect allergens in allergen-containing meals). To judge these parameters, we examined a large assortment of meals: roughly half contained our goal allergen, and the opposite half didn’t. We then benchmarked our expertise in opposition to customary industrial allergen detection kits: lateral movement units (LFDs).
The meals examined encompassed over 300 substances and have been bought from a wide range of sources. Whereas lots of the meals have been chosen for ingredient variety, some have been chosen for his or her difficult chemical and bodily properties to raised assess the Amulet’s limitations and capabilities.
Our findings exhibit that our sensors supply superior efficiency to commercially customary allergen detection strategies like LFDs. As one instance, LFD kits usually generated an inconclusive end result for extremely viscous meals. The Amulet, conversely, was capable of accurately determine the presence of soy in these similar meals.
An fascinating edge case for the Amulet was a unfavorable readout for vegetable oil, which is highly-refined soybean oil. Whereas this may appear surprising, analysis has proven that highly-refined soybean oil—together with its by-product, soy lecithin—has little, if any, soy allergen current. It’s because the refinement course of reduces the quantity of soy allergen to ranges beneath that which might set off an allergic response within the overwhelming majority of soy-allergic people. For that reason, most allergists don’t advise their soy-allergic sufferers to keep away from soy lecithin. Our take a look at end result was additionally confirmed by a unfavorable readout from the LFD package.
We have been happy (however not totally stunned) to seek out that for 100% of the meals examined, the Amulet accurately detected the presence or absence of soy. These outcomes have been per these of the LFD, but the Amulet was additional capable of detect soy allergen in instances the place the LFD package gave an inconclusive readout.
After all, nothing is 100% correct; however this knowledge provides us confidence that we’re outperforming main industrial allergen detection applied sciences in each accuracy and velocity.
The excessive accuracy and sensitivity of the Amulet additional underscores its worth as a preventative instrument for avoiding allergenic meals.
The variety of meals combos is countless, however our work establishes that in all situations we flagged as potential sources of error, the Amulet carried out with a excessive diploma of accuracy. We look ahead to constructing on our soy testing outcomes, and publishing detection knowledge on different allergenic substances and meals contaminants our sensors are at present detecting!
For a deeper dive, you may learn our newest peer-reviewed publication right here.
— The Allergy Amulet Science Crew